Preprint / Version 1

What Causes Elevated Lipoprotein A and How do we Manage It?

##article.authors##

  • Alexia Hoffman Polygence

DOI:

https://doi.org/10.58445/rars.3434

Keywords:

Lipoprotein A (Lp(a)), Cardiovascular Disease (CVD), Wound Healing, Endothelial Cells, Therapeutic Development, Lifestyle Factors, Inflammation

Abstract

Lipoprotein A (Lp(a)) is a lipid that performs various functions due to its unique structure. Lp(a) is an independent risk factor for Cardiovascular Disease (CVD). Lp(a) testing is recommended for people of all ages because high Lp(a) can lead to CVD. This study explores elevated Lp(a) levels and how to reduce them, providing potential medicines including pharmaceutical interventions or environmental factors. Understanding Lp(a)’s impact on Cardiovascular health is important to minimize health risks. This paper explores the causes of elevated Lp(a), analyzes current pharmacologic and environmental management strategies, and explores emerging therapies, highlighting the importance of regular Lp(a) screening and targeted treatment in controlling cardiovascular risk caused by Lp(a).

References

Ekelund, U.; Steene-Johannessen, J.; Brown, W. J.; Fagerland, M. W.; Owen, N.; Powell, K. E.; Bauman, A.; Lee, I.-M.; Lancet Physical Activity Series 2 Executive Committe; Lancet Sedentary Behaviour Working Group. Does Physical Activity Attenuate, or Even Eliminate, the Detrimental Association of Sitting Time with Mortality? A Harmonised Meta-Analysis of Data from More than 1 Million Men and Women. Lancet Lond. Engl. 2016, 388 (10051), 1302–1310. https://doi.org/10.1016/S0140-6736(16)30370-1.

BC-ADM, S. K., PharmD, FCCP, BCPS, BCACP. Epidemiology and Management of Hyperlipidemia | AJMC. https://www.ajmc.com/view/epidemiology-and-management-of-hyperlipidemia-article (accessed 2025-11-04).

Volgman, A. S.; Koschinsky, M. L.; Mehta, A.; Rosenson, R. S. Genetics and Pathophysiological Mechanisms of Lipoprotein(a)-Associated Cardiovascular Risk. J. Am. Heart Assoc. 2024, 13 (12), e033654. https://doi.org/10.1161/JAHA.123.033654.

Sara, P. Cardiovascular Disease (CVD): The Overview. 2018.

How high blood pressure can affect the body. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/high-blood-pressure/art-20045868 (accessed 2025-11-04).

Downloads

Posted

2025-11-13

Categories

License

Copyright (c) 2025 Alexia Hoffman

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license