The Cancer Stem Cell Hypothesis
DOI:
https://doi.org/10.58445/rars.3664Keywords:
Cancer stem cells, CSC hypothesis, Ovarian CancerAbstract
Approximately 80% of patients with ovarian cancer experience relapse (Primeau). Cancer stem cells (CSCs) are proposed to be the primary drivers of tumor growth, treatment resistance, and relapse. However, the extent of their role in this is a topic that remains debated. This paper explores the CSC hypothesis, its role in the growth of tumors, therapy resistance, and possible targeted therapies. Knowing how big of a role cancer stem cells have in the growth and treatment of cancer is crucial to knowing what the next steps are in cancer research and treatment.
References
Primeau, Andrea. “Cancer Recurrence Statistics.” Cancer Therapy Advisor, 30 Nov. 2018, www.cancertherapyadvisor.com/factsheets/cancer-recurrence-statistics/.
O'Flaherty, John D et al. "The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer vol. 7,12 (2012): 1880-1890. doi:10.1097/JTO.0b013e31826bfbc6
Najafi, Masoud, et al. "Cancer Stem Cell (CSC) Resistance Drivers." Life Sciences, vol. 234, Oct. 2019, p. 116781, https://doi.org/10.1016/ j.lfs.2019.116781
Rasetyanti, Pramudita, and Jan Medema. "Intra-tumor heterogeneity from a cancer stem cell perspective." Molecular Cancer. Molecular Cancer, molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0600-4. Accessed 16 Feb. 2017.
Doe, R. John. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh, 1998. Print.
Xie, Xuanhua P et al. "Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy."Developmental cell vol. 57,1 (2022): 32-46.e8. doi:10.1016/ J.devcel.2021.12.007
Yoo, Min-Hyuk, and Dolph L. Hatfield. "The cancer stem cell theory: is it correct?" Molecules and cells 26.5 (2008): 514-516.
Verhagen, Mathijs P, et al. “Non-Stem Cell Lineages as an Alternative Origin of Intestinal Tumorigenesis in the Context of Inflammation.” Nature Genetics, vol. 56, no. 7, 20 June 2024, pp. 1456–1467, www.nature.com/articles/s41588-024-01801-y, https://doi.org/10.1038/s41588-024-01801-y. Accessed 24 Feb. 2025.
Duan, Hongxia et al. "Recent advances in drug delivery systems for targeting cancer stem cells." Acta pharmaceutica Sinica. B vol. 11,1 (2021): 55-70. doi:10.1016/j.apsb.2020.09.016
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