The Role of Genetics in Depression and Its Implications for Individualized Treatment
DOI:
https://doi.org/10.58445/rars.3792Keywords:
Genetics, Depression, TreatmentAbstract
Depression is a mental health disorder characterized by prolonged sadness and anhedonia–the loss of enjoyment in previously enjoyable activities. An estimated 332 million people, or about 4% of the world population, are affected by depression. It is caused by a combination of genetic and environmental factors, and depending on an individual’s genetic predisposition, the associated risk may greatly vary. Prolonged periods of depressive episodes significantly impact the daily lives of those affected and can lead to self-harm or suicide. The most common forms of treatment are antidepressants and psychotherapy, but these vary based on the person affected. Despite decades of research on depression, there is still much unknown about the condition. This review explores the role of genetics in depression and how treatment options can vary based on individual genetic and environmental differences.
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