Advances in CAR-T therapy, Checkpoint Inhibitors and TKI for Pediatric Acute Lymphoblastic Leukemia
DOI:
https://doi.org/10.58445/rars.3917Keywords:
CAR-T therapy, Pediatric Acute Lymphoblastic Leukemia, LeukemiaAbstract
Acute lymphoblastic leukemia (ALL) is a cancer affecting the blood and bone marrow, marked by the overproduction of immature white blood cells called lymphoblasts. It is, notably, the most common form of cancer in children. Between 1998 and 2016, the number of ALL cases annually reported has increased from 110,000 to 200,000. With the growing number of cases each day, it is paramount to find improved and more advanced treatments. This study aims to explore the effectiveness of several new therapies—checkpoint inhibitors, CAR-T therapy, and TKI treatment— in comparison to more traditional treatments used to treat pediatric ALL. By evaluating the advantages and limitations of these new therapies, this study aims to offer insights into the future of pediatric ALL and improve patient survival rates. Additionally, this study could help influence clinical decision-making and inspire new and improved therapies that allow young patients to continue to live a normal life while battling this challenging disease.
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