Examining mechanisms underlying how spinal cord injuries worsen neuroimmune signaling and immune function
DOI:
https://doi.org/10.58445/0m8ntg44Keywords:
spinal cord, spinal cord injur, inflammationAbstract
Spinal cord injury (SCI) is defined as damage to the bundle of nerves and nerve fibers that transmit signals throughout the body. SCI is commonly linked to paralysis and loss of sensation, but it can also have a profound impact on the immune system. Examples of these impacts include changes in the timing of the immune response, immune organ dysfunction, and excessive inflammation. The present literature review examines the consequences of SCI on immune function, evaluating changes in inflammatory signaling, immune organ function, and communication between the nervous and immune systems. Evidence suggests that SCI can cause overactive inflammation and immune suppression, leaving one vulnerable to infections and other long-term complications. The severity of these effects often depends on the region where the injury happens as well as the completeness of the injury. Recent studies have suggested classifying SCI as a neurological and immunological disorder and that a deeper understanding of neuroimmune interactions may help in developing better future treatments and patient outcomes.
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