Preprint / Version 1

Improving ACL Reconstruction Outcomes with NeuroBrace: A Clinical and Economic Framework

##article.authors##

  • Gyan Desai Vista Ridge High School
  • David Tong

DOI:

https://doi.org/10.58445/rars.4032

Keywords:

ACL reconstruction, Arthrogenic Muscle Inhibition (AMI), Quadriceps atrophy, NeuroBrace

Abstract

Nearly  200,000 individuals in the United States  undergo Anterior Cruciate Ligament (ACL) reconstruction annually Still, the standard post-surgery recovery methods  have not  changed in decades. Conventional braces stabilize the joint but do not address arthrogenic muscle inhibition (AMI), which is a  reflex mechanism that lowers the activity of the quadriceps  after injury, resulting in rapid quad atrophy and secondary rupture rates in more than  20% young athletes. Here, we  propose NeuroBrace, which is a closed-loop orthotic pairing surface EMG (sEMG) sensors with targeted neuromuscular electrical stimulation (NMES) to detect and correct activation deficits, while equipping clinicians with objective compliance data. By implementing  conceptual meta-synthesis of published sEMG, NMES, and landing-biomechanics studies , we model how consistent use of the feedback loop could accelerate quad hamstring co-activation symmetry and reduce risk of re-injury, and pair that with a cost model built on Remote Therapeutic Monitoring reimbursement codes to estimate savings from shifting rehab out of the clinic and into an AI guided home protocol. 

References

Wiggins, Andrew J., et al. “Risk of Secondary Injury in Younger Athletes After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.” The American Journal of Sports Medicine, 2016. PubMed Central, PMC5501245.

“Michigan Initiative for Anterior Cruciate Ligament Rehabilitation (MiACLR).” ClinicalTrials.gov, National Institutes of Health, 2018, Identifier NCT03626857.

Lamplot, Jeffrey D., and Robert H. Brophy. “Current Concepts in Hip and Core Assessment to Reduce the Risk of ACL Injury.” International Journal of Sports Physical Therapy, 3 Feb. 2026.

Clermont, Caroline A., et al. “Rethinking the Assessment of Arthrogenic Muscle Inhibition After ACL Reconstruction: Implications for Return-to-Sport Decision-Making, A Narrative Review.” PubMed Central, 2025, PMC12027548.

Dupont, Julien, et al. “The Effect of Physiotherapy on Arthrogenic Muscle Inhibition After ACL Injury or Reconstruction: A Systematic Review.” PubMed Central, 2025, PMC11678747.

Lepley, Lindsey K., et al. “Arthrogenic Muscle Inhibition After Anterior Cruciate Ligament Injury: Injured and Uninjured Limb Recovery Over Time.” Frontiers in Physiology, 2023, PMC10072230.

Paterno, Mark V., et al. “Biomechanical Measures During Landing and Postural Stability Predict Second Anterior Cruciate Ligament Injury After ACL Reconstruction and Return to Sport.” The American Journal of Sports Medicine, vol. 38, 2010, PMID 20702858.

Howells, Benjamin, et al. “Use of Electromyographic Biofeedback in Rehabilitation Following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.” Physiotherapy, 2023, doi:10.1016/j.physio.2023.03.002.

Grooms, Dustin R., et al. “Neurocognitive and Neuromuscular Rehabilitation Techniques After ACL Injury, Part 1: Optimizing Recovery in the Acute Post-Operative Phase, A Clinical Commentary.” International Journal of Sports Physical Therapy, 16 June 2025.

Toth, Matthew J., et al. “Utility of Neuromuscular Electrical Stimulation to Preserve Quadriceps Muscle Fiber Size and Contractility After Anterior Cruciate Ligament Injuries and Reconstruction: A Randomized, Sham-Controlled, Blinded Trial.” The American Journal of Sports Medicine, vol. 48, 2020, PMID 32631074.

Snyder-Mackler, Lynn, et al. “Effects of Neuromuscular Electrical Stimulation After Anterior Cruciate Ligament Reconstruction on Quadriceps Strength, Function, and Patient-Oriented Outcomes: A Systematic Review.” Journal of Orthopaedic and Sports Physical Therapy, 2010.

Pietrosimone, Brian, et al. “The Effect of Neuromuscular Electrical Stimulation on Quadriceps Strength and Knee Function in Professional Soccer Players: Return to Sport After ACL Reconstruction.” PubMed Central, 2013, PMC3870113.

Gholipour, Mohammad, et al. “Neuromuscular Electrical Stimulation Enhances Lower Limb Muscle Synergies During Jumping in Martial Artists Post-Anterior Cruciate Ligament Reconstruction: A Randomized Crossover Trial.” PubMed Central, 2025, PMC12109262.

Zhou, Xin, et al. “Biomechanical Research on ACL: A Narrative Bibliometric Analysis.” European Journal of Physical Education and Sport Science, Nov. 2025.

Patel, K., et al. “Biomechanical Assessment Tools for Injury Risk Prediction and Return-to-Sport Evaluation in Athletes: A Systematic Review.” PubMed Central, 2025, PMC12553509.

GlobeNewswire. “Digital Health for Musculoskeletal Care Analysis Report 2025: Global Market to Surpass $11.5 Billion by 2030, Growing at a CAGR of 17.7%.” GlobeNewswire, 15 Jan. 2025.

ResearchAndMarkets.com. “Digital Therapeutics Market Outlook Report 2026–2034: $61.29 Billion Opportunities.” GlobeNewswire, 13 Nov. 2025.

SNS Insider. “Telerehabilitation Market Size Projected to Hit USD 15.4 Billion by 2032, Growing at a CAGR of 14.1%.” GlobeNewswire, 17 Jan. 2025.

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Posted

2026-08-13